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iloperidone raises levels of ethinylestradiol by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe. Iloperidone is often a time-dependent CYP3A inhibitor and will produce elevated plasma levels of medicines predominantly eradicated by CYP3A4.rifampin will lessen the level or influence of ethinylestradiol by influencing he